Products
Products
Explore our advanced sequencing products for turning complex molecular signals into high-confidence readouts across clinical testing, RNA quality control, and translational methylation programs.
NeuroLens®
Neuron Cell-Death Test
RNA Clarity™
RNA Vaccine QC
MethylMap™
Native-Read Methylation Sequencing
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Services
Services
End-to-end sequencing services supporting genomic, epigenomic, and transcriptomic analysis, from experimental design and assay development to bioinformatics, interpretation, and data delivery.
Applications
Applications
Explore how our products and services help solve difficult biological and genomic problems, from liquid biopsy signals to complex regions and emerging biomarker development.
Hard-to-Sequence Genes & Complex Regions
Liquid Biopsy cfDNA Analysis
Targeted Panel Development
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Company
Company
Building the future of precision diagnostics through sequencing innovation, scientific rigor, and collaborative partnerships.
About Us
Development & Validation
Team
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Resources
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  • Applications
  • Applications
    Telomeres, the protective caps at the end of our chromosomes, sit at the intersection of aging, cancer, and neurodegeneration research.
    Telomeres, the protective caps at the end of our chromosomes, sit at the intersection of aging.
    Research & Translation
    Biopharma Research
    Clinical Development
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Case Study
October 14, 2025

Targeted Long-Read Sequencing for Translational Oncology Case Study

Previous characterization work has demonstrated that Renew Biotechnologies (Renew) Direct Targeted Methylation Sequencing (dTMS) platform enables accurate detection of single-nucleotide variants (SNVs), short tandem repeats (STRs), haplotypes, and regional DNA methylation within a unified targeted long-read workflow. Here, we apply this hybrid capture-based approach to HCT116 colorectal carcinoma cells using the Agilent SureSelect Colon Cancer panel, demonstrating high-accuracy SNV detection and methylation profiling across targeted loci. These results highlight the potential of dTMS for integrated genomic and epigenetic profiling, supporting scalable multi-omic assay development within translational oncology.

Download the Case Study

Additional Resources
White Paper
October 10, 2025
Direct Targeted Methylation Sequencing Feature Characterization White Paper
Publication
October 31, 2023
Neuron-Derived cfDNA Detection by Methylation Sequencing
Publication
February 23, 2026
ModSeqR: Efficient Modified Nucleotide Sequencing Analysis
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