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  • Applications
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    Telomeres, the protective caps at the end of our chromosomes, sit at the intersection of aging, cancer, and neurodegeneration research.
    Telomeres, the protective caps at the end of our chromosomes, sit at the intersection of aging.
    Research & Translation
    Biopharma Research
    Clinical Development
  • Company
  • Company
    Building the future of precision diagnostics through sequencing innovation, scientific rigor, and collaborative partnerships.
    About Us
    Team
Oxford Nanopore Technologies Service

Telomere Sequencing

  • A native long-read sequencing service for direct telomere length measurement and subtelomeric structure characterization.
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Overview

Telomere Sequencing is a specialized Oxford Nanopore Technologies (ONT) service for native long-read analysis of telomere length, subtelomeric structure, and adjacent epigenetic features. The workflow supports molecule-level characterization of telomere biology from extracted DNA without live-cell processing.
  • Arm-specific telomere length measurement across chromosome ends
  • Integrated subtelomeric methylation and structural variant analysis
  • Native DNA workflow using fresh or biobanked samples
  • Scalable study designs across research and translational applications
Telomere Characterization
Global and chromosome arm-specific telomere length analysis
Identification of short telomeres and telomere length heterogeneity
Subtelomeric Profiling
Subtelomeric methylation and DMR characterization
Structural variant and adjacent genomic context analysis
Research & Translational Applications
Aging, oncology, and telomere biology research
Biomarker discovery and longitudinal cohort studies
Technology
Workflow
Performance
Data Outputs

Technology and Compatibility

Telomere Sequencing applies specialized ONT long-read sequencing chemistry to high-molecular-weight genomic DNA, enabling direct measurement of telomere length and subtelomeric structure from native DNA molecules.
  • Compatible with
  • High-molecular-weight DNA from human and other eukaryotic organisms
  • Fresh, frozen, cultured, and biobanked DNA samples
  • Research, translational, and telomere biology workflows
  • Component
    Technology
  • Sequencing Chemistry
    Native Oxford Nanopore DNA Sequencing
  • Preparation
    ONT-compatible telomere adapter ligation and enrichment
  • Sequencing Platform
    Oxford Nanopore PromethION

Workflow

Telomere Sequencing uses ONT’s specialized long-read telomere sequencing workflow for direct measurement of telomere length and subtelomeric structure from native DNA. Renew provides full-service support from high molecular weight (HMW) gDNA extraction through library preparation, sequencing, analysis, and data delivery.
  • 1. HMW gDNA Extraction
    High-quality genomic DNA is isolated from samples
  • 2. Library Preparation
    DNA is prepared using ONT-compatible Telo-Seq library preparation
  • 3. Long-Read Sequencing
    Native DNA sequencing is performed on the PromethION platform.
  • 4. Data Analysis
    Sequencing data are processed through automated analysis pipelines.
  • 5. QC Reporting
    Arm-level TL distributions, subtelomeric context visualizations
  • 6. Data Delivery
    Results are delivered through the customer portal or AWS S3.

Sequencing Performance

Coverage and yield vary depending on sample inputs such as, tissue type, type of organism, and coverage requirements. Download the dWMS white paper to view performance across different inputs. The following performance metrics assume human tissue as the species, but the service can be performed on any organism of interest.
Comparison table of Legacy Assays and WBL Teloseq by input, output, resolution, logistics, insight, scalability, throughput.
  • Metric
    Typical Performance (Human Samples)
  • Samples per Flow Cell
    Up to 12
  • Telomere Coverage
    Minimum 10 reads per chromosome arm
  • Average Read Length
    Long telomere-spanning reads
  • Replicate Precision
    Technical replicate concordance (r ≥ 0.95)
  • CpG Coverage
    > 95% CpG coverage
  • Available Epigenetic Signals
    5mC, 5hmC, 6mA, non-CpG methylation

Bioinformatics and Data Outputs

Data outputs are designed to optimize data storage, transfer, and analysis. Methylation data is provided in a unique CH3 file format which reduces data size by up to 95%. This memory-efficient format stores data in an on-disk database, enabling larger-than-memory tasks.
Renew developed the ModSeqR R package, which converts ONT methylation data into array-like formats compatible with tools such as minfi, DMRcate, and chAMP. This solution empowers researchers to efficiently leverage dWMS data within familiar frameworks, facilitating advanced epigenetic insights.
Get ModSeqR on GitHub
Download panel showing four files for specimen 250409 with names, sizes, dates, and download options.
  • Data Outputs
  • QC Report
    Sequencing metrics and run statistics
  • BAM
    Aligned reads
  • CH3
    Base modifications
  • POD5
    Raw sequencing data (available for an additional fee)
  • Data Delivery Options
  • Client Web Portal
    Manual download | Mac, Linux, Windows
  • AWS S3 Transfer
    Automated process | AWS to AWS
  • Command Line Script
    Manual download | Mac, Linux

Service Inclusions

Each project is supported by dedicated project management and cross-functional expertise across assay development, bioinformatics, and regulatory strategy. Renew provides proactive communication, transparent project tracking, and technical support from study design through data delivery.
Renew combines platform flexibility, nanopore expertise, and operational excellence to resolve areas
of the genome that standard approaches cannot.
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