Whole-Genome Sequencing

Whole-Genome Sequencing supports applications requiring higher genomic coverage, including genome assemblies, rare variant discovery, comparative genomics, biomarker and translational research, and integrated genomic and epigenomic characterization across human, animal, plant, microbial, and non-model organisms.

Oxford Nanopore WGS sequences native DNA as long reads without bisulfite conversion or PCR amplification, enabling characterization of larger complex genomic features and native epigenetic modifications that are difficult to resolve with short-reads.

Whole-Genome Sequencing supports detection of single nucleotide variants (SNVs), insertions and deletions (indels), large structural and copy number variants, haplotypes, phased genomes, and native DNA methylation (5mC, 5hmC, and 6mA), enabling integrated genomic and epigenomic analysis.

Recommended sequencing depth depends on the study objectives, sample type, genome size, and intended analyses. Renew works with each project team to recommend appropriate coverage for applications such as genome assembly, variant detection, methylation analysis, or multiomic characterization.

Whole-Genome Sequencing is compatible with high-quality genomic DNA from human, animal, plant, microbial, and other non-model organisms. Sample input requirements are provided during project planning.

Deliverables typically include raw sequencing data, basecalled reads, quality control metrics, aligned sequence files (when applicable), and variant and methylation outputs. Bioinformatics analyses can be customized based on project goals and downstream analysis requirements.

Every project includes consultation on experimental design, sequencing strategy, QC, and data analysis. Renew's team provides project management, bioinformatics support, flexible data delivery, and technical consultation from study design through final data interpretation.