Case Study
October 13, 2025

Scalable Oncology Insights with dWMS Case Study

This case study highlights the utility of 5x direct Whole Methylome Sequencing (dWMS) for multi-omic biomarker discovery in oncology. By downsampling 30x ONT datasets from ovarian, lung, and lymphoma tumor samples, we demonstrate that low-pass dWMS enables cost-effective, high-confidence detection of genome-wide CpG methylation and large structural variants (SVs). These findings position dWMS as a powerful platform for translational research and clinical assay development.

Download the Case Study