Unlocking the Plant and Animal Epigenome
DNA methylation is a fundamental epigenetic modification that governs gene expression, development, and adaptation across eukaryotes. For plants and animals, understanding methylation patterns can provide key insights into phenotypic plasticity and diversity, environmental resilience, and evolutionary processes. However, accessing this wealth of information—especially in non-model organisms—remains hindered by technical challenges and outdated methodologies.
Traditional approaches, including bisulfite sequencing and MeDIP, often introduce biases, degrade DNA, or fail to fully capture methylation in complex genomic regions. These limitations leave major gaps in our understanding, especially for repetitive and polyploid genomes or species with unique methylation landscapes.
Renew Biotechnologies (Renew) bridges this gap with Direct Whole Methylome Sequencing (dWMS), an advanced platform built on Oxford Nanopore Technologies. dWMS directly detects native methylation without requiring bisulfite conversion or synthetic amplification, delivering high-resolution, whole-genome methylation insights across species. With dWMS, researchers can confidently decode the biological significance of methylation across diverse taxa.
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