Spec Sheet
October 15, 2026

Direct Whole Methylome Sequencing Spec Sheet

Direct Whole Methylome Sequencing (dWMS) is Renew's low-pass whole-genome sequencing service optimized for native DNA methylation analysis. Combining proprietary library preparation with native Oxford Nanopore sequencing, dWMS enables genome-wide methylation profiling without bisulfite conversion or PCR amplification while simultaneously capturing native sequence information from the same dataset.

Designed for scalable methylome characterization, dWMS provides a flexible alternative to methylationarrays for translational research, regional methylation analysis, and non-model species epigenomics.

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