Direct Targeted Methylation Sequencing Feature Characterization White Paper

This study characterizes Renew Biotechnologies’ (Renew) Direct Targeted Methylation Sequencing (dTMS) assay for integrated detection of genetic variants and DNA methylation within defined target regions. Using Agilent SureSelect hybrid capture technology, proprietary Renew library preparation methods, and native long-read nanopore sequencing, we enriched targeted loci and evaluated performance in established reference DNA. The assay delivered robust on-target efficiency and sufficient coverage to accurately resolve SNPs, STRs, haplotypes, and regional methylation in a single workflow, supporting scalable, targeted multi-omic applications.

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